National collaboration

• • Istituto Nazionale di Fisica Nucleare (INFN)-Laboratori Nazionali del Sud (LNS)
  • Università degli Studi di Catania – Prof.ssa Rosalba Parenti, Ph.D. Laboratorio di Fisiologia Cellulare e Molecolare e Vice-Direttore Dipartimento di Scienze Biomediche e Biotecnologiche. Titolare Delegato Stabilimento Utilizzatore Unico e Area Preclinica – CAPiR Torre Biologica – Via S. Sofia, 89, 95123 Catania CT, Italia
  • Consigliere dalla SIRR – Società Italiana per le Ricerche sulle Radiazioni
  • Filiera del Radiofarmaco costituita da Università degli Studi di Catania, LNS-INFN – H-Cannizzaro e IBFM – CNR

International collaboration

• • Samuel Valable, PhD, CNRS   Scientist – ISTCT Lab UMR 6030– CNRS, CEA , UNICAEN (istct.cyceron.fr) Co-leader CERVOxy group Scientific director of ONCOModels
  • Walter Tinganelli Phd. Clinical Radiobiology Group Leader GSI (Helmholtzzentrum fuÃàr Schwerionenforschung GmbH). Biophysics department, Darmstadt, Germany.

• • The role of hypoxia and SRC tyrosine kinase in glioblastoma invasiveness and radioresistance. Filippo Torrisi, Nunzio Vicario 1, Federica M. Spitale , Francesco P. Cammarata, Luigi Minafra , Lucia Salvatorelli , Giorgio Russo , Giacomo Cuttone , Samuel Valable , Rosario Gulino , Gaetano Magro and Rosalba Parenti. Cancers 2020.
  • Molecular Investigation on a Triple Negative Breast Cancer Xenograft Model Exposed to Proton Beams. Cammarata FP, Forte GI, Broggi G, Bravatà V, Minafra L, Pisciotta P, Calvaruso M, Tringali R, Tomasello B, Torrisi F, Petringa G, Cirrone GAP, Cuttone G, Acquaviva R, Caltabiano R, Russo G. Int J Mol Sci. 2020 Sep 1;21(17):E6337. doi: 10.3390/ijms21176337. PMID: 32882850
  • SRC Tyrosine Kinase Inhibitor and X-rays Combined Effect on Glioblastoma Cell Lines. Filippo Torrisi †, Luigi Minafra, Francesco P. Cammarata* , Gaetano Savoca , Marco Calvaruso , Nunzio Vicario , Laura Maccari , Elodie A. Pérès5 , Hayriye Özçelik , Myriam Bernaudin , Lorenzo Botta , Giorgio Russo , Rosalba Parenti ,* and Samuel Valable  Int J Mol Sci. 2020 May 30;21(11):E3917. doi: 10.3390/ijms21113917. PMID: 32486205
  • Evaluation of proton beam radiation-induced skin injury in a murine model using a clinical SOBP. Pietro Pisciotta, Angelita Costantino, Francesco Paolo Cammarata*, Filippo Torrisi, Giovanna Calabrese, Valentina Marchese, Giuseppe Antonio Pablo Cirrone, Giada Petringa, Giusi Irma Forte, Luigi Minafra, Valentina Bravatà, Massimo Gulisano, Fabrizio Scopelliti, Francesco Tommasino,Emanuele Scifoni, Giacomo Cuttone, Massimo Ippolito, Rosalba Parenti, Giorgio Russo. PLOS ONE. jttps://doi.org/10.1371/journal.pone.0233258 May 22, 202
  • MF2C3: Multi-Feature Fuzzy Clustering to Enhance Cell Colony Detection in Automated Clonogenic Assay Evaluation. Carmelo Militello* , Leonardo Rundo , Luigi Minafra , Francesco Paolo Cammarata , Marco Calvaruso , Vincenzo Conti and Giorgio Russo. Symmetry 2020, 12(5), 773; https://doi.org/10.3390/sym12050773
  • Nutraceutical Compounds as Sensitizers for Cancer Treatment in Radiation Therapy. Calvaruso M, Pucci G, Musso R, Bravatà V, Cammarata FP, Russo G, Forte GI, Minafra L. Int J Mol Sci. 2019 Oct 23;20(21). pii: E5267. doi: 10.3390/ijms20215267. PMID: 31652849
  • Proton Therapy and Src Family Kinase Inhibitor Combined Treatments on U87 Human Glioblastoma Multiforme Cell Line. Francesco P Cammarata,†, Filippo Torrisi,†, Giusi I Forte, Luigi Minafra,*, Valentina Bravatà, Pietro Pisciotta, Gaetano Savoca, Marco Calvaruso, Giada Petringa, Giuseppe AP Cirrone, Anna L Fallacara, Laura Maccari, Maurizio Botta, Silvia Schenone, Rosalba Parenti, Giacomo Cuttone and Giorgio Russo. International Journal of Molecoular Science.
  • Radiosensitizing effect of curcumin-loaded lipid nanoparticles in breast cancer cells. Luigi Minafra, Nunziatina Porcino, Valentina Bravatà, Daniela Gaglio, Marcella Bonanomi, Erika Amore, Francesco Paolo Cammarata, Giorgio Russo, Carmelo Militello, Gaetano Savoca, Margherita Baglio, Boris Abbate, Giuseppina Iacoviello, Giovanna Evangelista, Maria Carla Gilardi, Maria Luisa Bondì & Giusi Irma Forte. Scientific Reportsvolume 9, Article number: 11134 (2019)
  • Sensitization of chondrosarcoma cells with PARP inhibitor and high-LET radiation. Césaire M, Ghosh U, Austry JB, Muller E, Cammarata FP, Guillamin M, Caruso M, Castéra L, Petringa G, Cirrone GAP, Chevalier F. J Bone Oncol. 2019 Jun 20;17:100246. doi: 10.1016/j.jbo.2019.100246. 2019 Aug.
  • Gene Expression Profiles Induced by High-dose Ionizing Radiation in MDA-MB-231 Triple-negative Breast Cancer Cell Line. Bravatà V, Cammarata FP, Minafra L, Musso R, Pucci G, Spada M, Fazio I, Russo G, Forte GI. Cancer Genomics Proteomics. 2019 Jul-Aug;16(4):257-266. doi: 10.21873/cgp.20130.
  • Betula etnensis Raf. (Betulaceae) Extract Induced HO-1 Expression and Ferroptosis Cell Death in Human Colon Cancer Cells. Malfa GA, Tomasello B, Acquaviva R, Genovese C, La Mantia A, Cammarata FP, Ragusa M, Renis M, Di Giacomo C. Int J Mol Sci. 2019 Jun 3;20(11). pii: E2723. doi: 10.3390/ijms20112723.
  • Proton-irradiated breast cells: molecular points of view. Valentina Bravatà, Francesco P. Cammarata, Luigi Minafra, Pietro Pisciotta, Concetta Scazzone, Lorenzo Manti, Gaetano Savoca, Giada Petringa, Giuseppe A.P. Cirrone, Giacomo Cuttone, Maria C. Gilardi, Giusi I. Forte and Giorgio Russo. Journal of Radiation Research, 2019, pp. 1–15 doi: 10.1093/jrr/rrz032

  • Breast cancer cells treated with proton beam: Immunological features and gene signatures. Francesco P. Cammarata, Valentina Bravatà, Luigi Minafra, Pietro Pisciotta, Rosa Musso, Gaia Pucci, Concetta Scazzone, Lorenzo Manti, Carmelo Militello, Giada Petringa, Giuseppe A. P. Cirrone, Giacomo Cuttone, Maria C. Gilardi, Giorgio Russo and Giusi Irma Forte. IL NUOVO CIMENTO 41 C (2018) 202. DOI 10.1393/ncc/i2018-18202-9. Colloquia SIRR 2018
  • Preliminary study of novel SRC tyrosine kinase inhibitor and proton therapy combined effect on glioblastoma multiforme cell line: In vitro evaluation of target therapy for the enhancement of protons effectiveness. Luigi Minafra, Francesco P. Cammarata, Filippo Torrisi, Giusi I. Forte, Valentina Bravatà, Marco Calvaruso, Pietro Pisciotta, Carmelo Militello, Giada Petringa, Giuseppe A. P. Cirrone, Anna L. Fallacara, Laura Maccari, Maurizio Botta, Giacomo Cuttone and Giorgio Russo. IL NUOVO CIMENTO 41 C (2018) 203. DOI 10.1393/ncc/i2018-18203-8. Colloquia SIRR 
  • Radiobiological quantities in proton-therapy: Estimation and validation using Geant4-based Monte Carlo simulations.Petringa G, Romano F, Manti L, Pandola L, Attili A, Cammarata F, Cuttone G, Forte G, Manganaro L, Pipek J, Pisciotta P, Russo G, Cirrone GAP. Phys Med. 2019 Feb;58:72-80. doi: 10.1016/j.ejmp.2019.01.018. Epub 2019 Feb 5. PMID: 30824153
  • Raman spectroscopy to evaluate radiobiological sensitivity of normal human breast cells at different time points after irradiation by a clinical proton beam. Maria Lasalvia, Giuseppe Perna,  Pietro Pisciotta,  Francesco Paolo Cammarata,  Lorenzo Manti  and  Vito Capozzi. 2019 Analyst, 2019, DOI: 10.1039/C8AN02155D. IF 3.8
  • Monte Carlo GEANT4-based application for in vivo RBE study using small animals at LNS-INFN preclinical hadrontherapy facility P. Pisciotta, P. Cammarata, A. Stefano, F. Romano, V. Marchesea,, F. Torrisi, G.I. Forte, L. Cella, G.A.P. Cirrone, G. Petringa, M.C. Gilardi, G. Cuttone, G. Russo. European Journal of Medical Physics
  • Gene expression profiling of breast cancer cell lines treated with proton and electron radiations. Bravatà V, Minafra L, Cammarata FP, Pisciotta P, Lamia D, Marchese V, Petringa G, Manti L, Cirrone GA, Gilardi MC, Cuttone G, Forte GI, Russo G. Br J Radiol. 2018 Jul 5:20170934. doi: 10.1259/bjr.20170934.
  • Radiation Gene-expression Signatures in Primary Breast Cancer Cells. Minafra L, Bravatà V, Cammarata FP, Russo G, Gilardi MC, Forte GI. Anticancer Res. 2018 May;38(5):2707-2715. PMID: 29715090
  • Radiation-Induced Gene Expression Changes in High and Low Grade Breast Cancer Cell Types. Valentina Bravatà, Claudia Cava, Luigi Minafra, Francesco Paolo Cammarata, Giorgio Russo, Maria Carla Gilardi, Isabella Castiglioni and Giusi Irma Forte. J. Mol. Sci. 2018, 19, 1084; doi:10.3390/ijms19041084.
  • First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness G. A. P. Cirrone, L. Manti, D. Margarone, G. Petringa, L. Giuffrida, A. Minopoli, A. Picciotto, G. Russo, F. Cammarata, P. Pisciotta, F. M. Perozziello, F. Romano,V. Marchese, G. Milluzzo, V. Scuderi, G. Cuttone & G. Korn. Scientific Reports 8, Article number: 1141 (2018) doi:10.1038/s41598-018-19258-5
  • Area-based cell colony surviving fraction evaluation: A novel fully automatic approach using general-purpose acquisition hardware. Militello C, Rundo L, Conti V, Minafra L, Cammarata FP, Mauri G, Gilardi MC, Porcino N. Comput Biol Med. 2017 Sep 5;89:454-465. doi: 10.1016/j.compbiomed.2017.08.005. PMID: 28886482
  • SASPects of Radiation Induced SenescenceLuigi Minafra, Valentina Bravatà, Francesco Paolo Cammarata, Federica Maria Di Maggio and Giusi Irma Forte. Annals of Radiation Therapy and Oncology 2017. Ann Radiat Ther Oncol. 2017; 1(2): 1006.
  • Radiogenomics: the utility in patient selection. Forte, GI; Minafra, L; Bravata, V; Cammarata, FP; Lamia, D; Pisciotta, P; Cirrone, GAP; Cuttone, G; Gilardi, MC; Russo, G. TRANSLATIONAL CANCER RESEARCH Volume: 6  Pages: S852-S874  Supplement: 5  Special Issue: SIDOI: 10.21037/tcr.2017.06.47. JUL 2017
  • Cytokine profile of breast cell lines after different radiation doses. Bravatà V, Minafra L, Forte GI, Cammarata FP, Russo G, Di Maggio FM, Augello G, Lio D, Gilardi MC. Int J Radiat Biol. 2017 Sep 1:1-10. doi: 10.1080/09553002.2017.1362504. PMID: 28763256
  • High-Intensity Focused Ultrasound and Radiation Therapy–Induced Immuno-Modulation: Comparison And Potential Opportunities. Roberta Cirincione, Federica Maria Di Maggio,Y Giusi Irma Forte, Luigi Minafra,Valentina BravatA, Laura Castiglia, Vincenzo Cavalieri, Giovanni Borasi, Giorgio Russo, Domenico Lio, Cristina Messa, Maria Carla Gilardi, and Francesco Paolo Cammarata. Ultrasound in Med. & Biol., Vol. 43, No. 2, pp. 398–411, 2017
  • Radiation therapy towards laser-driven particle beams: an “OMICS” approach in radiobiology. Capitolo di libro. ISSN: 1618-7210; DOI: 10.1007/978-3-319-31563-8
  • Preliminary study for small animal preclinical hadrontherapy facility. G. Russo, P. Pisciotta, G.A.P. Cirrone, F. Romano, F. Cammarata, V. Marchese, G.I. Forte, D. Lamia, L. Minafra, V. Bravatá, R. Acquaviva, M.C.Gilardi, G.Cuttone. Nuclear Inst. and Methods in Physics Research, A. doi.org/10.1016/j.nima.2016.10.021
  • Specific protein changes contribute to the differential muscle mass loss during ageing. Capitanio D, Vasso M, De Palma S, Fania C, Torretta E, Cammarata FP, Magnaghi V, Procacci P, Gelfi C. Proteomics. 2016 Feb;16(4):645-56. doi: 10.1002/pmic.201500395.
  • Rapporti Tecnici – Collana dei rapporti tecnici annuali dell’Istituto di Bioimmagini e Fisiologia Molecolare (IBFM) –CNR. Radiobiological investigations in breast cancer cells
  • Caveolin-1, Breast Cancer and Ionizing Radiation. Pucci M, Bravatà V, Forte GI, Cammarata FP, Messa C, Gilardi MC, Minafra L. Cancer Genomics Proteomics. 2015 05-06;12(3):143-152. Review.
  • Gene Expression Profiling of MCF10A Breast Epithelial Cells Exposed to IOERT. Minafra, L, Bravata, V, Russo, G, Forte, GI, Cammarata, FP, Ripamonti, M, Candiano, G, Cervello, M, Giallongo, A, Perconti, G Messa, C,  Gilardi, MC. Anticancer Res. Jun 2015 35(6):3223-34.
  • High-dose Ionizing Radiation Regulates Gene Expression Changes in the MCF7 Breast Cancer Cell Line. Bravatà V, Minafra L, Russo G, Forte GI, Cammarata FP, Ripamonti M, Casarino C, Augello G, Costantini F, Barbieri G, Messa C, Gilardi MC. Anticancer Res. 2015 May;35(5):2577-91.
  • DVWA gene polymorphisms and osteoarthritis. Bravatà V, Minafra L, Forte GI, Cammarata FP, Saporito M, Boniforti F, Lio D, Gilardi MC, Messa C. BMC Res Notes. 2015 Feb 4;8(1):30.
  • Portrait of inflammatory response to ionizing radiation treatment. Federica Maria Di Maggio, Luigi Minafra, Giusi Irma Forte, Francesco Paolo Cammarata, Domenico Lio, Cristina Messa, Maria Carla Gilardi, Valentina Bravatà. Journal of inflammation (Lond. Online)
  • “Opportunities from modulating Ultrasound, from tissue ablation to tissue regeneration”. Cammarata FP, Forte GI. Translational Cancer Research “High Intensity Focused Ultrasounds (HIFU)” issue 2014. Transl Cancer Res 2014 Sep 10. doi: 10.3978/j.issn.2218-676X.2014.09.04.
  • A daily quality assurance routine for ultrasounds in vitro experiments. Vicari F, Russo G, Cammarata FP, Cirincione R, Forte GI, Borasi G, Gilardi MC Translational Cancer Research “High Intensity Focused Ultrasounds (HIFU)” issue 2014. Transl Cancer Res 2014 Sep 15. doi: 10.3978/j.issn.2218-676X.2014.09.02.
  • Theoretical and experimental study of the role of cell-cell dipole interaction in dielectrophoretic devices: application to polynomial electrodes. Camarda M, Fisicaro G, Anzalone R, Scalese S, Alberti A, La Via F, La Magna A, Ballo A, Giustolisi G, Minafra L, Cammarata FP, Bravatà V, Forte GI, Russo G, Gilardi MC. Biomed Eng Online. 2014 Jun 5;13:71.
  • Gene expression profiling of epithelial-mesenchymal transition in primary breast cancer cell culture. Minafra L, Bravatà V, Forte GI, Cammarata FP, Gilardi MC, Messa C. Anticancer Res. 2014 May;34(5):2173-83.
  • Genetic, clinical and radiographic signs in knee osteoarthritis susceptibility. Luigi Minafra, Valentina Bravatà, Michele Saporito, Francesco P Cammarata, Giusi I Forte, Salvatore Caldarella, Michele D’Arienzo, Maria C Gilardi, Cristina Messa and Filippo Boniforti. Arthritis Research & Therapy 2014, 16:R91.
  • Glucose starvation induces cell death in K-ras-transformed cells by interfering with the hexosamine biosynthesis pathway and activating the unfolded protein response. R Palorini, FP Cammarata, C Balestrieri, A Monestiroli, M Vasso, C Gelfi, L Alberghina and F Chiaradonna. Cell Death and Disease 2013; 4, e732.
  • Genotyping analysis and FDG uptake in breast cancer patients: a preliminary research. Bravatà V, Stefano A, Cammarata FP, Minafra L, Russo G, Nicolosi S, Pulizzi S, Gelfi C, Gilardi MC and Messa C. Journal of Experimental & Clinical Cancer Research, 2013; 30;32:23
  • “Omics” of HER2 Positive Breast Cancer. Bravatà V, Cammarata FP, Forte GI, Minafra L. 2013; 17:119-29.